Résumé

Introduction: Hyperprolactinemia is an endocrine disorder with diverse etiologies. Drug-induced hyperprolactinemia is not uncommon. We report the case of a patient who developed hyperprolactinemia after taking levosulpiride . Clinical case: Mrs. L., B., aged 43, was referred to our clinic for galactorrhea that had been present for approximately one month. Two months prior , the patient had consulted a physician for headaches and vertigo associated with nausea and a few episodes of vomiting. The patient received treatment with second-line analgesics, an anti-vertigo medication, and a combination of prokinetics and an antiemetic. Approximately six weeks after the start of treatment , The patient noticed breast tenderness , followed by a milky discharge upon breast pressure, without any menstrual cycle irregularities. A pituitary MRI was normal, but her prolactin level was elevated at 40 ng /ml . During our consultation, the patient reported consistent use of levosulpiride 25 mg tablets ( Dislep 25 mg), one tablet three times a day for one month. The rest of the pituitary workup was unremarkable. Management consisted of discontinuing the prokinetic agent . Two weeks later, a reduction in breast tenderness was noted. One month after stopping the medication, her serum prolactin level was 29 ng / ml , and her dyspeptic symptoms were well controlled with a proton pump inhibitor. Conclusion: Due to the increasing use of levosulpiride , greater awareness of its effect on serum prolactin levels appears necessary, particularly to reduce diagnostic errors and streamline further investigations.

Mot-clés :

Hyperprolactinemia; Levosulpiride, Adverse Effect, Galactorrhea